Carnosic Acid

Product name: Carnosic Acid
Source: Rosemary leaf
Specifications : 5%,10%,50%,90%,98%
Appearance : Brown yellow powder
CAS No: 3650-09-7
Test Method: HPLC
Shelf Life: 2 Years
Certs: GMP, ISO9001, ISO22000, HACCP, KOSHER, HALAL
Content: Natural, Non-additive,Non-GMO,Treat by Heat Only

Description

High Quality Rosemary Extract Carnosic Acid Powder

Rosemary extract carnosic acid powder manufacturer KINTAI - A leader herbal extract factory in China and certified ISO GMP HACCP qualifications.

KINTAI manufacturer have the high quality carnosic acid powder with the pure specification from 5% to 98%.

We also provide OEM one-stop service, welcome contact us for further information!

Carnosic Acid powder with fresh rosemary
KINTAI manufacturer gained GMP certificate for Macleaya Cordata extract

What is carnosic acid powder?

Carnosic acid is a polyphenol compound extracted from the rosemary plant. The rosemary plant is a herb that grows in the Mediterranean region and other warm climates. Its leaves are rich in volatile oils and a variety of active ingredients, and carnosic acid is an important component.

Chemical formula: C20H28O4

Molecular weight: 332.43

CAS No: 3650-09-7

Solubility: The Carnosic acid powder can easily soluble in grease and organic solvents such as ethanol, ethyl acetate, acetone, chloroform, etc. But insoluble in water.

the molecular formula of Carnosic Acid

Specification

Product NameSourceCAS No
Carnosic Acid powderRosemary leaf3650-09-7
Analysis ItemsSpecificationTest method
Assay of Carnosic Acid98%HPLC
Physical and chemical properties
AppearanceBrown yellow powderVisual
OdourUniqueOrganoleptic
Particle Size≥99% Through 80 meshCh.P.C.Rule47
Ash≤5.0%Ch.P.C.Rule2302
Loss on drying≤5.0%Ch.P.C.Rule52
Heavy Metals of Carnosic Acid powder≤10.0ppmAtomic Absorption
Cadmium(Cd)≤1.0ppmAtomic Absorption
Mercury(Hg)≤0.1ppmAtomic Absorption
Arsenic(As)≤1.0ppmAtomic Absorption
Lead(Pb)≤2.0ppmAtomic Absorption
Residual Solvents
– Ethanol≤1000 PPMGas Chromatography
Microbiological Quality (Total viable aerobic count) of Carnosic Acid powder
Total Plate Count,cfu/g≤1000 CFU/gCh.P.C.Rule80
Mold and yeast Count,cfu/g≤ 100 CFU/gCh.P.C.Rule80
E. coliNegativeCh.P.C.Rule80
SalmonellaNegativeCh.P.C.Rule80
Staphylococcus aureusNegativeCh.P.C.Rule80
*Storage Condition: Store in tightly closed plastic bag and keep in a cool dry place. Keep always from strong direct light.
*KINTAI Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO

Function Of Carnosic Acid

Carnosic acid powder is suitable for antioxidant use in oil-soluble ingredients. Our manufacturer produced carnosic acid is widely used for both antioxidant, antiseptic and preservation of edible oils, fried foods, sauces, dairy products, meat, aquatic products and candies.
It has a variety of health-promoting effects, such as delaying aging, enhancing weight loss and lipid lowering, antibacterial, anti-inflammatory, treating cardiovascular disease and anti-cancer effects, also has broad application prospects in the biomedical and cosmetic industries.

1. Antibacterial effect:

Carnosic acid powder has a certain antibacterial effect, can inhibit the growth of bacteria and fungi and help prevent infections.

Studies have shown that rosemary extract carnosic acid has inhibitory effects on Staphylococcus aureus, Escherichia coli, both Bacillus subtilis and Hansenula yeasts. It is also be used as a food preservative.

Inhibit oral bacteria: It can inhibit the growth of oral bacteria. Not only prevent dental caries and bad breath, but also keep the oral cavity clean and healthy. In short it binds to strep bacteria in the mouth, preventing them from producing acid and sticking to teeth.

2. Anti-tumor:

Rosemary extract carnosic acid can inhibit proliferation and induce apoptosis on a variety of human cancer cells. Such as breast cancer, colon cancer, prostate cancer, and liver cancer.
It can exert its anti-tumor effects by regulating cell cycle, also activating mitochondrial pathway and extrinsic pathway. Eventually inhibiting angiogenesis and metastasis.
Studies have found that carnosic acid has an inhibitory effect on the proliferation of HL-60 cells. So it is expected to become a new drug for the treatment of hematological malignancies, cardiovascular disease and anti-cancer.
Kaloustian et al. introduced that carnosic acid powder also have certain therapeutic effects on heart disease and respiratory diseases. It have antibacterial effects, and can also inhibit HIV infection.

3. Anti-inflammatory :

Carnosic acid can inhibit inflammatory reactions, reduce inflammatory symptoms, and has a certain effect in the treatment of inflammatory diseases.
Studies have found that carnosic acid maintains the stability of the body's redox system by regulating oxidative stress-related signaling pathways such as Nrf2-Keap1 and NF-κB.
It has good preventive and therapeutic effects on oxidative damage-related diseases such as neurological diseases, cardiovascular diseases, liver damage, renal fibrosis, retinopathy, etc.
At the same time, it can also inhibit the production of inflammatory mediators such as prostaglandin E2, interleukin, tumor necrosis factor α, etc., thereby reducing the inflammatory response. 

Carnosic Acid have Anti-inflammatory function
3D structure
have Antibacterial function good for health

4. Natural antioxidant :

Carnosic acid has a powerful antioxidant effect and can neutralize free radicals, protect cells from oxidative damage, and delay the aging process.
Its DPPH, ABTS free radical scavenging ability and iron reducing antioxidant ability are stronger than VE, slightly weaker than the synthetic antioxidant TBHQ. Also its restoration ability is stronger than VE and TBHQ2.
In addition, studies have found that carnosic acid can effectively scavenge oxygen free radicals in mouse liver cells. It can reduce the production of lipid peroxides, and thereby stabilize the cell membrane.
Carnosic acid can also inhibit the oxidation reaction of low-density lipoprotein, which can effectively prevent the occurrence of atherosclerosis.

The antioxidant mechanism of carnosic acid mainly includes the following aspects:
  • Free radical scavenging
    Carnosic acid can directly scavenge a variety of free radicals, such as DPPH, ABTS, OH, etc., thereby blocking the transmission of free radical chain reactions. Carnosic acid can also react with peroxide free radicals to generate stable endocyclic peroxides , thereby neutralizing the damage caused by peroxide free radicals to living organisms.
  • Inhibit lipid peroxidation
    Carnosic acid can effectively inhibit the peroxidation reaction of polyunsaturated fatty acids in oils, thereby delaying the deterioration and discoloration of oils. Carnosic acid can also protect unsaturated fatty acids on cell membranes from free radical attacks, thereby maintaining the fluidity of cell membranes. and function.
  • Protect DNA
    DNA is one of the most important molecules in living systems and one of the most vulnerable targets to free radical damage. DNA damage can lead to mutations, aberrations or breaks, which can cause genetic defects or cause cancer. Carnosic acid can not only protect DNA from oxidative damage by free radicals, thereby maintaining the integrity and stability of DNA. Carnosic acid can also enhance cells' ability to repair DNA damage, thereby preventing adverse consequences caused by DNA damage.
Carnosic Acid can treat Oxidative Stress
antioxidant can protect skin

5. Reduce blood pressure :

Carnosic acid blocks the production of angiotensin II by inhibiting the activity of angiotensin-converting enzyme (ACE), dilating blood vessels and lowering blood pressure. So far there is an antihypertensive drug in Japan using it as the main ingredient, called Stevia®, which has passed clinical trials and proven its safety and effectiveness.

6. Hypoglycemic :

Rosemary extract carnosic acid powder can lower blood sugar levels by inhibiting the expression of glucose transporter (GLUT). Reducing glucose absorption and utilization, consequently lowering blood sugar levels. This is very beneficial for diabetics.

7. Cardiovascular Protection:

Carnosic acid helps lower cholesterol levels and prevent the development of atherosclerosis and cardiovascular disease.

8. Neuroprotective:

Studies have revealed the neuroprotective effects of carnosic acid. When used as a preventive or therapeutic agent, carnosic acid can reduce damage to nervous system tissue, therefore playing a unique role in the treatment of neurodegenerative diseases.

9. Stable and resistant to high temperatures:

Our KINTAI manufacturer produced carnosic acid powder has the characteristics of both high efficiency, safety, non-toxic, stable and high temperature resistance. It can delay the oxidation of oily food, improve the stability of food and extend the storage period. The most important it is a pure natural green food additive. Therefore, it have widely usage in food, biomedicine, chemical, cosmetics and feed industries.

10. Other functions:

Ninomiya et al. reported that rosemary extract carnosic acid powder , in addition to controlling people’s weight by regulating fat absorption to achieve weight loss, can also treat inflammation, treat sore throat, treat indigestion, and prevent Alzheimer’s disease. Treat diabetes, and promote the production of nerve growth factors.

Carnosic Acid powder have Neuroprotective function
heart Cardiovascular strengthen

Application of rosemary extract carnosic acid powder

As a natural antioxidant, carnosic acid has good biocompatibility, safety and effectiveness, so our KINTAI manufacturer produced carnosic acid powder has broad application prospects in food, cosmetics, medicine and other fields.

1. Natural food additives

Carnosic acid powder can be used as a natural food preservative to extend the shelf life of food and maintain the color, aroma and nutritional value of food.

It also can be a functional food ingredient to prevent or treat diseases, such as cardiovascular disease, obesity, cancer, etc.

2. Beverages and food

Carnosic acid powder can be added into the beverages and foods, such as beverages, juices, dairy products, desserts, candies and condiments, etc. It can replace or reduce traditional sweeteners and provide a more natural and healthy sweetness. For example, in Japan, it has a widely uses in various products, such as Coca-Cola, Sprite, 7Up and other soft drinks.

Carnosic Acid is natural food additive
KINTAI manufacturer Carnosic Acid is a raw material of cosmetic

3. Flavors and fragrances

It has a fresh and fragrant smell so can be used as a raw material in the manufacture of various perfumes, cosmetics, detergents and other products. Carnosic acid can also be used as a bacteriostatic disinfectant for cleaning and sterilization.

4. Cosmetic raw materials

As a cosmetic raw material, it is added to cosmetics and skin care products. It has antioxidant and anti-aging effects can inhibit skin aging, improve skin elasticity, moisturize and whiten the skin. Carnosic acid powder also can be raw material of anti-inflammatory and anti-itching products, for treating skin allergies, redness, dryness and other problems.

5. Medicine and health care

Carnosic acid, as a natural herbal ingredient, is widely used in medicine and health care. Accordingly use its antioxidant, blood pressure lowering, blood sugar lowering and other functions to prevent or improve some chronic diseases or skin problems. It can also be used to treat inflammatory diseases, cardiovascular diseases, infections and other diseases.

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Shipping & Packaging
  • Packaging: Inside food grade bag, outer aluminum foil bag. 
    25kg use double-layer plastic container/fiber drum.
    Or your choice.
  • OEM Service Available: Customized packaging available, click here to know more.
  • Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA
  • American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.
  • Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.

Please contact us and we will guide you with an easy and professional way for your order.

About Us
ISO GMP HACCP Certified Factory

KINTAI BIOTECH INC.

WE ARE LEADER IN HERBAL EXTRACTS MARKET SINCE 2012

ISO GMP Certificate
FAQ
Are you a manufacturer or trading company?

We are manufacturer.

What is MOQ?

Our MOQ is flexible from 0.1kg to 1kg, please contact us for details.

What are your prices?

Our prices are depending on supply and market factors, we will send you an updated price list after contact us for further information.

What's your lead time?

Most products we have in stock can be delivered within 3 working days, customized products need further confirmation.

What is your payment terms?

We accept payment by T/T, L/C, Paypal, Wester Union:
Please contact us and we will guide you with an easy and professional way for your order.

Can I get free sample for test?

Yes, free sample available.

How to guarantee the product is qualified?

Our GMP factory have complete quality control system with 100,000 level clean production workshop, and every batch must be 100% passed by QC.

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