Aconitum medicinal uses, analgesic Lappaconitine Hydrobromide

The root of the plant Aconitum contains the active ingredient lappaconitine, which has important medicinal uses in pharmaceutical intermediates.
Lappaconitine Hydrobromide is a new non-addictive analgesic pharmaceutical ingredient with anti-inflammatory and analgesic effects, local anesthesia, anti-inflammatory, and relieve swelling effects.

Due to its long-lasting analgesic effect and high safety, it has a wide application in the pharmaceutical industry. Now let’s take a look at what medicinal uses aconitum root extract lappaconitine have.

Aconitum medicinal uses

1. Analgesic effect

The Ministry of Health of China stipulates that Lappaconitine Hydrobromide is a moderate analgesic for cancer patients. Aconitum root extract Lappaconitine Hydrobromide has an analgesic effect when administered by different routes. It has no teratogenic and mutagenic effects, and will not accumulate and cause poisoning. It can exert a strong and lasting analgesic effect.

The analgesic effect of Lappaconitine Hydrobromide is comparable to that of pethidine, and is 7 times more effective than aminopyrine. It is a commonly used alternative to tramadol. Studies show that the analgesic effect of aconite Lappaconitine Hydrobromide is slower than that of pethidine, but the analgesic effect lasts longer and is non-addictive.

2. Local anesthetic effect

Aconitum root extract Lappaconitine Hydrobromide has a local anesthetic effect, and the analgesic effect of infiltration anesthesia is stronger than that of cocaine and procaine. Accordingly, the local corneal anesthetic effect of 0.1% Lappaconitine Hydrobromide is equivalent to that of 0.84% ​​cocaine. And the conduction-blocking effect on the sciatic nerve is 5.25 and 13 times that of cocaine and procaine respectively.

3. Anti-inflammatory and Reduce swelling 

Lappaconitine Hydrobromide can enhance local blood circulation, promote the absorption and disappearance of inflammation, and therefore have a significant inhibitory effect on swelling caused by inflammations. People use the active ingredients of Aconitum root extract to eliminate swelling in the auricle, toes, joints, lower limbs, and other parts.
The anti-inflammatory effect of subcutaneous injection of Lappaconitine Hydrobromide 1.5mg/kg is 66 times that of aspirin. The anti-inflammatory and relieve swelling effect of intraperitoneal injection of aconite root extract Lappaconitine Hydrobromide 4 mg/kg is equivalent to 50 mg/kg of aminopyrine.

4. Anti-tumor effect

Lannaconitine has a certain inhibitory effect on cancer cells. Its strong analgesic and immune balance effects are widely used for late-stage cancer analgesia and perioperative analgesia. Some patients with malignant tumors can improve their general condition during the application process, such as increased appetite, improved spirit, improved immune indicators, and changes in blood counts.

5. Cooling and fever relief 

Aconitum root extract Lappaconitine Hydrobromide can relieve the fever, it mainly exerts its antipyretic effect by increasing the norepinephrine content in the synaptic cleft, thereby inhibiting the release of substance P that can stimulate the heat production center.

6. Antiarrhythmic effect

Studies have found that small doses of Aconitum root extract Lappaconitine Hydrobromide have antiarrhythmic effects, while large doses can induce arrhythmias.

7. Regulate immunity

Aconitum root extract Lappaconitine Hydrobromide can enhance the phagocytic ability of white blood cells and mononuclear macrophages. Meanwhile, it can also regulate and improve immune function.

Above all, our KINTAI supplies high-quality aconitum root extract Lappaconitine Hydrobromide, which has superb medicinal uses and hot sale in many countries as a pharm ingredient.

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