Black Pepper Extract Piperine, 95% 98% Bioperine cGMP Factory

High Quality Black Pepper Extract Piperine Powder

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KINTAI has high-quality Piperine powder with the pure specification of 95%, 98%, and other customized specs available.

We also provide OEM one-stop service, such as capsules, tablets, private packages, and labels, welcome contact us for further information!

What is Piperine?

Piperine, or bioperine, is a natural alkaloid powder extracted from black pepper. It generally exists in the dried near-ripe or mature fruits of Piper nigrum L., a plant in the Piperaceae family, and is usually from black pepper. Piperine is found in the fruits of various pepper plants and is the main ingredient of its spicy flavor. The market has black pepper and white pepper, and the content of piperine is 5% to 9%, sometimes as high as 11%.

Origin: In 1819, a yellow powder piperine was first extracted from pepper. In addition, pepper extracts contain various alkaloids such as piperolein B, pipericine, piperylin A, and piperonine , which also have spicy and stimulating tastes. Piperine also has the highest content and highest activity among all alkaloids in pepper.

Piperine Extract Source: Pepper is popular as the "king of spices", black pepper and white pepper are the most common types on the market.

Plant Pepper is grown in tropical and subtropical areas such as Guangdong, Guangxi, and Yunnan in China. Harvest when the fruit is dark green from late autumn to the following spring. After drying, it will be "black pepper". If all the fruits have turned red, harvest it. Soak it in water for several days, wipe off the outer peel, and dry it in the sun, then it is gray-white inside as "white pepper".

Product name: Piperine, Bioperine

Source: Piper nigrum L.

CAS No: 94-62-2

Chemical formula: C17H19NO3

Molecular weight: 285.34

Color: White to light yellow powder

Solubility: Soluble in acetic acid, ethanol and chloroform, slightly soluble in ether.

Safety: Piperine is relatively safe and does not show any negative effects even when taken in high doses. It has also obtained GRAS certification from the US FDA.

Specification of Black Pepper Extract Piperine

Product Name	Source	CAS No
Black pepper extract piperine powder	Piper nigrum L.	94-62-2
Analysis Items	Specification	Test method
Assay of piperine	95%	HPLC
Physical and chemical properties
Appearance	light yellow powder	Visual
Odour	Unique	Organoleptic
Particle Size	≥99% Through 80 mesh	Ch.P.C.Rule47
Ash	≤5.0%	Ch.P.C.Rule2302
Loss on drying	≤5.0%	Ch.P.C.Rule52
Heavy Metals of Piperine powder	≤10.0ppm	Atomic Absorption
Cadmium(Cd)	≤1.0ppm	Atomic Absorption
Mercury(Hg)	≤0.1ppm	Atomic Absorption
Arsenic(As)	≤1.0ppm	Atomic Absorption
Lead(Pb)	≤2.0ppm	Atomic Absorption
Residual Solvents
– Ethanol	≤1000 PPM	Gas Chromatography
Microbiological Quality (Total viable aerobic count) of Piperine powder
Total Plate Count,cfu/g	≤1000 CFU/g	Ch.P.C.Rule80
Mold and yeast Count,cfu/g	≤ 100 CFU/g	Ch.P.C.Rule80
E. coli	Negative	Ch.P.C.Rule80
Salmonella	Negative	Ch.P.C.Rule80
Staphylococcus aureus	Negative	Ch.P.C.Rule80
*Storage Condition: Store in tightly closed plastic bag and keep in a cool dry place. Keep always from strong direct light.
*KINTAI Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO

Function and Application

Piperine extract from black pepper has the effects of bioavailability promotion, antioxidant, anti-inflammatory and analgesic, sedative, neuroprotective, and anti-depressant. It is used to treat symptoms such as cold stomach and abdominal pain, arthritis, epilepsy, depression, and rough skin. It also has anti-convulsant and weight-loss functions, can increase the body's metabolic rate, and improve blood circulation.

Piperine powder is widely used in medical, food, drinks, cosmetics, and healthcare products, now let's take a look at the details.

Function of black pepper extract piperine

1. Bioavailability Promotion

Bioavailability is an important indicator of the degree of absorption and utilization by the body.

Piperine powder has been used as a bioavailability enhancer for over 20 years. It improves bioavailability when taken with most nutrients: water or oil-soluble vitamins, multivitamins, plant extracts, minerals, and other nutrients.

Studies have shown that BioPerine can increase the absorption rate of curcumin by 20 times. Piperine can also enhance the permeability of the small intestinal epithelial cell membrane, improving the absorption of Q10 and other nutrients in the small intestine.

Therefore, when taking turmeric supplements, you can check whether there is black pepper (piperine) added to it, then the turmeric can be better absorbed. In addition, piperine is relatively safe, so you don’t have to worry about side effects if you consume too much.

2. Anti-inflammatory

Piperine, the main active ingredient in black pepper, can reduce inflammation.

In a rat study, staining showed that piperine significantly reduced areas of inflammation in the ankle joint, with less joint swelling and fewer inflammatory markers.

3. Antioxidant effect

As the active compound in black pepper, piperine powder is rich in antioxidants, it can prevent and delay the damaging effects of free radicals from outside, therefore protecting the body from oxidative stress.

4. Effects on the central nervous system

Piperine has Neuroprotective, sedative, hypnotic, anti-convulsant, skeletal muscle relaxation, and anti-depressant effects. Studying the effect of piperine on animal sleep, shows that piperine can significantly reduce the spontaneous activities of mice and extend the sleep time of mice. It can also obviously increase the deep sleep of rabbits.

Serving piperine also improves brain function by reducing the production of amyloid plaques, the damaging proteins associated with Alzheimer's disease.

One study designed a model of Alzheimer's disease and gave adult male Wistar rats piperine. After 10 weeks, Wistar's memory impairment in the hippocampus improved significantly, and cognitive function increased a lot.

5. Lose weight

Nature Piperine extract may reduce weight by improving insulin and leptin sensitivity.

6. Anticonvulsant

In traditional Chinese medicine, doctors use black pepper to stop convulsions. stop convulsions. Because piperine has anticonvulsant properties and can help regulate neurohormonal levels and enhance nerve regeneration and cell protection.

7. Other Function

In traditional Chinese medicine, black pepper extract can treat: warm the stomach (treat indigestion, abdominal pain, loss of appetite, also diarrhea), dispel colds (treat common colds and fevers), relieve pain (treat constipation, bloating, nausea, and cramps), and treat malaria.

In Ayurvedic medicine, people use black pepper to treat: cleanse, and detoxify (helps sweating and urination, removes toxins from the blood), help nutrient absorption, also help transport oxygen quickly to the brain, maintain respiratory health, repair and maintain joint health, and kill parasites.

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Mainly applications of piperine powder

1. As a medicinal raw material for arthritis, rheumatism, anti-inflammation, swelling, etc.
2. As an active ingredient in health care products for multiple purposes such as improving blood circulation and soothe nerves.
3. As an active ingredient in skincare products, used in the cosmetics industry.
4. Piperine also is widely used in food additives to make food taste richer and increase appetite.