Carnosic acid powder, cGMP factory wholesale bulk Carnosic

High Quality Rosemary Extract Carnosic Acid Powder

Rosemary extract carnosic acid powder manufacturer KINTAI - A leader herbal extract factory in China and certified ISO GMP HACCP qualifications.

KINTAI manufacturer have the high quality carnosic acid powder with the pure specification from 5% para 98%.

Também fornecemos serviço completo OEM, bem-vindo entre em contato conosco para mais informações!

What is carnosic acid powder?

Carnosic acid is a polyphenol compound extracted from the rosemary plant. The rosemary plant is a herb that grows in the Mediterranean region and other warm climates. Its leaves are rich in volatile oils and a variety of active ingredients, and carnosic acid is an important component.

Fórmula química: C20H28O4

Peso molecular: 332.43

Nº CAS: 3650-09-7

Solubilidade: The Carnosic acid powder can easily soluble in grease and organic solvents such as ethanol, acetato de etila, acetone, chloroform, etc.. But insoluble in water.

Especificação

Nome do Produto	Fonte	Nº CAS
Carnosic Acid powder	Folha de alecrim	3650-09-7
Itens de análise	Especificação	Método de teste
Assay of Carnosic Acid	98%	HPLC
Propriedades físicas e químicas
Aparência	Pó amarelo marrom	Visual
Odor	Exclusivo	Organoléptico
Tamanho da partícula	≥99% até 80 malha	Ch.P.C.Rule47
Cinzas	≤5,0%	Ch.P.C.Rule2302
Perda ao secar	≤5,0%	Ch.P.C.Rule52
Heavy Metals of Carnosic Acid powder	≤10,0 ppm	Absorção Atômica
Cádmio(Cd)	≤1,0 ppm	Absorção Atômica
Mercúrio(Hg)	≤0,1 ppm	Absorção Atômica
Arsênico(Como)	≤1,0 ppm	Absorção Atômica
Liderar(Pb)	≤2,0 ppm	Absorção Atômica
Solventes residuais
– Etanol	≤1000 PPM	Cromatografia em fase gasosa
Qualidade Microbiológica (Contagem aeróbica total viável) of Carnosic Acid powder
Contagem total de placas,UFC/g	≤1000 UFC/g	Ch.P.C.Rule80
Contagem de mofo e fermento,UFC/g	≤ 100 UFC/g	Ch.P.C.Rule80
E. coli	Negativo	Ch.P.C.Rule80
Salmonela	Negativo	Ch.P.C.Rule80
Staphylococcus aureus	Negativo	Ch.P.C.Rule80
*Condição de armazenamento: Armazene em saco plástico bem fechado e mantenha em local fresco e seco. Mantenha sempre longe da luz forte e direta.
*KINTAI promete todos os produtos: Não irradiado / Não-ETO/tratamento apenas por calor / Não OGM

Function Of Carnosic Acid

Carnosic acid powder is suitable for antioxidant use in oil-soluble ingredients. Our manufacturer produced carnosic acid is widely used for both antioxidant, antiseptic and preservation of edible oils, fried foods, sauces, dairy products, meat, aquatic products and candies.
It has a variety of health-promoting effects, such as delaying aging, enhancing weight loss and lipid lowering, antibacteriano, anti-inflamatório, treating cardiovascular disease and anti-cancer effects, also has broad application prospects in the biomedical and cosmetic industries.

1. Antibacterial effect:

Carnosic acid powder has a certain antibacterial effect, can inhibit the growth of bacteria and fungi and help prevent infections.

Studies have shown that rosemary extract carnosic acid has inhibitory effects on Staphylococcus aureus, Escherichia coli, both Bacillus subtilis and Hansenula yeasts. It is also be used as a food preservative.

Inhibit oral bacteria: It can inhibit the growth of oral bacteria. Not only prevent dental caries and bad breath, but also keep the oral cavity clean and healthy. In short it binds to strep bacteria in the mouth, preventing them from producing acid and sticking to teeth.

2. Anti-tumor：

Rosemary extract carnosic acid can inhibit proliferation and induce apoptosis on a variety of human cancer cells. Such as breast cancer, colon cancer, prostate cancer, and liver cancer.
It can exert its anti-tumor effects by regulating cell cycle, also activating mitochondrial pathway and extrinsic pathway. Eventually inhibiting angiogenesis and metastasis.
Studies have found that carnosic acid has an inhibitory effect on the proliferation of HL-60 cells. So it is expected to become a new drug for the treatment of hematological malignancies, cardiovascular disease and anti-cancer.
Kaloustian et al. introduced that carnosic acid powder also have certain therapeutic effects on heart disease and respiratory diseases. It have antibacterial effects, and can also inhibit HIV infection.

3. Anti-inflamatório ：

Carnosic acid can inhibit inflammatory reactions, reduce inflammatory symptoms, and has a certain effect in the treatment of inflammatory diseases.
Studies have found that carnosic acid maintains the stability of the body's redox system by regulating oxidative stress-related signaling pathways such as Nrf2-Keap1 and NF-κB.
It has good preventive and therapeutic effects on oxidative damage-related diseases such as neurological diseases, cardiovascular diseases, liver damage, renal fibrosis, retinopathy, etc..
At the same time, it can also inhibit the production of inflammatory mediators such as prostaglandin E2, interleukin, tumor necrosis factor α, etc., thereby reducing the inflammatory response.

4. Natural antioxidant ：

Carnosic acid has a powerful antioxidant effect and can neutralize free radicals, protect cells from oxidative damage, and delay the aging process.
Its DPPH, ABTS free radical scavenging ability and iron reducing antioxidant ability are stronger than VE, slightly weaker than the synthetic antioxidant TBHQ. Also its restoration ability is stronger than VE and TBHQ2.
Além disso, studies have found that carnosic acid can effectively scavenge oxygen free radicals in mouse liver cells. It can reduce the production of lipid peroxides, and thereby stabilize the cell membrane.
Carnosic acid can also inhibit the oxidation reaction of low-density lipoprotein, which can effectively prevent the occurrence of atherosclerosis.

The antioxidant mechanism of carnosic acid mainly includes the following aspects:

Free radical scavenging
Carnosic acid can directly scavenge a variety of free radicals, such as DPPH, ABTS, OH, etc., thereby blocking the transmission of free radical chain reactions. Carnosic acid can also react with peroxide free radicals to generate stable endocyclic peroxides , thereby neutralizing the damage caused by peroxide free radicals to living organisms.
Inhibit lipid peroxidation
Carnosic acid can effectively inhibit the peroxidation reaction of polyunsaturated fatty acids in oils, thereby delaying the deterioration and discoloration of oils. Carnosic acid can also protect unsaturated fatty acids on cell membranes from free radical attacks, thereby maintaining the fluidity of cell membranes. and function.
Protect DNA
DNA is one of the most important molecules in living systems and one of the most vulnerable targets to free radical damage. DNA damage can lead to mutations, aberrations or breaks, which can cause genetic defects or cause cancer. Carnosic acid can not only protect DNA from oxidative damage by free radicals, thereby maintaining the integrity and stability of DNA. Carnosic acid can also enhance cells' ability to repair DNA damage, thereby preventing adverse consequences caused by DNA damage.

5. Reduce blood pressure :

Carnosic acid blocks the production of angiotensin II by inhibiting the activity of angiotensin-converting enzyme (ACE), dilating blood vessels and lowering blood pressure. So far there is an antihypertensive drug in Japan using it as the main ingredient, called Stevia®, which has passed clinical trials and proven its safety and effectiveness.

6. Hypoglycemic :

Rosemary extract carnosic acid powder can lower blood sugar levels by inhibiting the expression of glucose transporter (GLUT). Reducing glucose absorption and utilization, consequently lowering blood sugar levels. This is very beneficial for diabetics.

7. Cardiovascular Protection:

Carnosic acid helps lower cholesterol levels and prevent the development of atherosclerosis and cardiovascular disease.

8. Neuroprotective:

Studies have revealed the neuroprotective effects of carnosic acid. When used as a preventive or therapeutic agent, carnosic acid can reduce damage to nervous system tissue, therefore playing a unique role in the treatment of neurodegenerative diseases.

9. Stable and resistant to high temperatures:

Our KINTAI manufacturer produced carnosic acid powder has the characteristics of both high efficiency, safety, non-toxic, stable and high temperature resistance. It can delay the oxidation of oily food, improve the stability of food and extend the storage period. The most important it is a pure natural green food additive. Portanto, it have widely usage in food, biomedicine, chemical, cosmetics and feed industries.

10. Other functions:

Ninomiya et al. reported that rosemary extract carnosic acid powder , in addition to controlling people’s weight by regulating fat absorption to achieve weight loss, can also treat inflammation, treat sore throat, treat indigestion, and prevent Alzheimer’s disease. Treat diabetes, and promote the production of nerve growth factors.

Application of rosemary extract carnosic acid powder

As a natural antioxidant, carnosic acid has good biocompatibility, safety and effectiveness, so our KINTAI manufacturer produced carnosic acid powder has broad application prospects in food, cosméticos, medicine and other fields.

1. Natural food additives

Carnosic acid powder can be used as a natural food preservative to extend the shelf life of food and maintain the color, aroma and nutritional value of food.

It also can be a functional food ingredient to prevent or treat diseases, such as cardiovascular disease, obesity, cancer, etc..

2. Beverages and food

Carnosic acid powder can be added into the beverages and foods, such as beverages, juices, dairy products, desserts, candies and condiments, etc.. It can replace or reduce traditional sweeteners and provide a more natural and healthy sweetness. For example, in Japan, it has a widely uses in various products, such as Coca-Cola, Sprite, 7Up and other soft drinks.

KINTAI manufacturer Carnosic Acid is a raw material of cosmetic

3. Flavors and fragrances

It has a fresh and fragrant smell so can be used as a raw material in the manufacture of various perfumes, cosméticos, detergents and other products. Carnosic acid can also be used as a bacteriostatic disinfectant for cleaning and sterilization.

4. Cosmetic raw materials

As a cosmetic raw material, it is added to cosmetics and skin care products. It has antioxidant and anti-aging effects can inhibit skin aging, improve skin elasticity, moisturize and whiten the skin. Carnosic acid powder also can be raw material of anti-inflammatory and anti-itching products, for treating skin allergies, redness, dryness and other problems.

5. Medicine and health care

Carnosic acid, as a natural herbal ingredient, is widely used in medicine and health care. Accordingly use its antioxidant, blood pressure lowering, blood sugar lowering and other functions to prevent or improve some chronic diseases or skin problems. It can also be used to treat inflammatory diseases, cardiovascular diseases, infections and other diseases.

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